Can Ince

Professor Can Ince is a physiologist at the at the Academic Medical Center (AMC), University of Amsterdam and Erasmus Medical Center (EMC), Erasmus University Rotterdam, The Netherlands. His chair in Clinical Physiology at the AMC is dedicated to cardiovascular aspects of surgery and intensive care focused on clinical and fundamental aspects of circulation and oxygenation. He heads the Department of Translational Physiology at the AMC. The Department consists of a group of basic and clinical scientist doing laboratory and clinical research in sepsis, shock, resuscitation, fluid therapy, blood transfusion, oxygen transport, microcirculation, mitochondria, acute kidney injury and heart failure. In addition medical technology research related to the afore mentioned topics is carried out. Since 2007 , he joined for 40% the Department of Intensive Care of the Erasmus Medical Center Rotterdam (prof Jan Bakker) where he also works in collaboration with the Dept of Pediatric and Neonatal Intensive Care of the Sophia Children's Hospital (Prof Tibboel and Prof Reis). This combination allows bench to bedside translation of concepts, diagnostic and therapeutic modalities related to circulation and oxygenation. He holds a PhD in Immunology/ Physiology and has a MSc and BSc in Electrical and Electronic Engineering. Prof Ince is past-president of the Dutch Physiological Society and past-president of the International Society of Oxygen Transport to Tissue. He has an H-index of 43, has authored over 300 peer reviewed papers and holds patents related to microcirculation technology.


Papers authored 2013, 2012

Almac E, Johannes T, Bezemer R, Mik EG, Unertl K, Groeneveld ABJ, Ince I (2013) Activated protein C ameliorates impaired renal microvascular oxygenation and sodium reabsorption in endotoxemic rat. Intensive Care Med Exp (in press)

Ince C, Groenveld ABJ (2013) The case for 0.9%Na Cl : Is the indefensible, defendable? Kidney International (review on invitation)

Zafrani L, Ince C, Yuen PS (2013) Microparticles during sepsis: target, canary or cure? Intensive Care Med. Aug 8. [

Vellinga NA, Ince C, Boerma EC.(2013) Elevated central venous pressure is associated with impairment of microcirculatory blood flow in sepsis: a hypothesis generating post hoc analysis. BMC Anesthesiol. 7;13(1):17

Meybohm P, Van Aken H, De Gasperi A, De Hert S, Della Rocca G, Girbes AR, Gombotz H, Guidet B, Hasibeder W, Hollmann MW, Ince C, Jacob M, Kranke P, Kozek-Langenecker S, Loer SA, Martin CD, Siegemund M, Wunder C, Zacharowski K (2013) Re-evaluating currently available data and suggestions for planning randomised controlled studies regarding the use of hydroxyethyl-starch in critically ill patients - a multidisciplinary statement. Crit Care. 26;17(4):R166.

Lupp C, Baasner S, Ince C, Nocken F, Stover JF, Westphal M (2013) Differentiated control of deranged nitric oxide metabolism: a therapeutic option in sepsis? Crit Care. 29;17(3):311

Hernandez G, Bruhn A, Luengo C, Regueira T, Kattan E, Fuentealba A, Florez J, Castro R, Aquevedo A, Pairumani R, McNab P, Ince C (2013) Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: a randomized, placebo-controlled, double-blind, crossover study. Intensive Care Med. 39(8):1435-43.

Yuruk K, Milstein DM, Bezemer R, Bartels B, Biemond BJ, Ince C (2013) Transfusion of banked red blood cells and the effects on hemorheology and microvascular hemodynamics in anemic hematology outpatients. Transfusion. 53(6):1346-52.

350. Ince C (2013) The Great Fluid Debate: When will physiology prevail? Anesthesiology. 119(2):248-9.

Okusa MD, Jaber BL, Doran P, Duranteau J, Yang L, Murray PT, Mehta RL, Ince C (2013) Physiological Biomarkers of Acute Kidney Injury: A Conceptual Approach to Improving Outcomes. Contrib Nephrol.182:65-81

Hernandez G, Boerma EC, Dubin A, Bruhn A, Koopmans M, Edul VK, Ruiz C, Castro R, Pozo MO, Pedreros C, Veas E, Fuentealba A, Kattan E, Rovegno M, Ince C (2013) Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients. J Crit Care 28(4):538

Tytgat SH, van der Zee DC, Ince C, Milstein DM (2013) Carbon dioxide gas pneumoperitoneum induces minimal microcirculatory changes in neonates during laparoscopic pyloromyotomy. Surg Endosc. PMID: 23539256

Marini JJ, Vincent JL, Wischmeyer P, Singer M, Gattinoni L, Ince C, Gan TJ (2013) Our favorite unproven ideas for future critical care. Crit Care. 2013;17 Suppl 1:S9.

Donati A, Tibboel D, Ince C (2013) Towards integrative physiological monitoring of the critically ill: from cardiovascular to microcirculatory and cellular function monitoring at the bedside. Crit Care. 17. Suppl 1:S5

Donati A, Domizi R, Damiani E, Adrario E, Pelaia P, Ince C. (2013) From macrohemodynamic to the microcirculation. Crit Care Res Pract. doi: 10.1155/2013/892710.

Hernandez G, Bruhn A, Ince C (2013) Microcirculation in sepsis: new perspectives. Curr Vasc Pharmacol. 11(2):161-9.

Ayhan B, Yuruk K, Koene S, Sahin A, Ince C, Aypar U (2013) The effects of non-leukoreduced red blood cell transfusions on microcirculation in mixed surgical patients. Transfus Apher Sci. 2013 doi:pii: S1473-0502(13)00032-3. 10.1016/

van Genderen ME, Bartels SA, Lima A, Bezemer R, Ince C, Bakker J, van Bommel J. (2013) Peripheral perfusion index as an early predictor for central hypovolemia in awake healthy volunteers. Anesth Analg. Feb;116(2):351-6.

340. Ince C, van Kuijen A, Milstein D, Yuruk K, Folkow L, Fokkens W, Blix, A (2012) Why Rudolph's nose is red. British Medical Journal 14;345-47

Evans RG, Ince C, Joles JA, Smith DW, May CN, O'Connor PM, Gardiner BS.(2013) Haemodynamic influences on kidney oxygenation: Clinical implications of integrative physiology. Clin Exp Pharmacol Physiol. 40(2):106-22.

Klijn E, Hulscher HC, Balvers RK, Holland WP, Bakker J, Vincent AJ, Dirven CM, Ince C (2013) Laser speckle imaging identification of increases in cortical microcirculatory blood flow induced by motor activity during awake craniotomy. J Neurosurg. 118(2):280-6

Enrico C, Kanoore Edul VS, Vazquez AR, Pein MC, Pérez de la Hoz RA, Ince C, Dubin A. J (2012) Systemic and microcirculatory effects of dobutamine in patients with septic shock. Crit Care. 27(6):630-8.

Hernandez G, Regueira T, Bruhn A, Castro R, Rovegno M, Fuentealba A, Veas E, Berrutti D, Florez J, Kattan E, Martin C, Ince C (2012) Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study. Ann Intensive Care. 15;2(1):44.

Smeele KM, Eerbeek O, Schaart G, Koeman A, Bezemer R, Nelson JK, Ince C, Nederlof R, Boek M, Laakso M, de Haan A, Drost MR, Hollmann MW, Zuurbier CJ (2012) Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis. J Appl Physiol 15;113(4):608-18.

Milstein DM, Cheung YW, Ziūkaitė L, Ince C, van den Akker HP, Lindeboom JA. (2012) An integrative approach for comparing microcirculation between normal and alveolar cleft gingiva in children scheduled for secondary bone grafting procedures. Oral Surg Oral Med Oral Pathol Oral Radiol. doi:pii: S2212-4403(12)00375-6. 10.1016/j.oooo.

Pozo MO, Kanoore Edul VS, Ince C, Dubin A (2012) Comparison of different methods for the calculation of the microvascular flow index. Crit Care Res Pract doi: 10.1155/2012/102483.

Özarslan NG, Ayhan B, Kanbak M, Çelebioğlu B, Demircin M, Ince C, Aypar Ü (2012) Comparison of the effects of sevoflurane, isoflurane, and desflurane on microcirculation in coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 26(5):791-8.

330. Hernandez G, Bruhn A, Castro R, Pedreros C, Rovegno M, Kattan E, Veas E, Fuentealba A, Regueira T, Ruiz C, Ince C (2012) Persistent Sepsis-Induced Hypotension without Hyperlactatemia: A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock. Crit Care Res Pract. 2012;2012:536852.

Kanoore Edul VS, Dubin A, Ince C (2012) The microcirculation as a therapeutic target in the treatment of sepsis and shock. Semin Respir Crit Care Med. 32(5):558-68.

Atasever B, Boer C, Speekenbrink R, Seyffert J, Goedhart P, de Mol B, Ince C (2012)Cardiac displacement during off-pump coronary artery bypass grafting surgery: effect on sublingual microcirculation and cerebral oxygenation. Interact Cardiovasc Thorac Surg. 13(6):573-7.

McMorrow RC, Windsor JS, Hart ND, Richards P, Rodway GW, Ahuja VY, O'Dwyer MJ, Mythen MG, Grocott MP; Caudwell Xtreme Everest Research Group (2012) Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m).Anaesthesia. 67(8):875-80.

Edul VS, Enrico C, Laviolle B, Vazquez AR, Ince C, Dubin A (2012) Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock. Crit Care Med. 40(5):1443-8.

Milstein DM, van Kuijen AM, Copper MP, Karakullukçu B, Tan IB, Lindeboom JA, Fokkens WJ, Ince C (2012) Monitoring microcirculatory alterations in oral squamous cell carcinoma following photodynamic therapy. Photodiagnosis Photodyn Ther. 9(1):69-75.

Levett DZ, Fernandez BO, Riley HL, Martin DS, Mitchell K, Leckstrom CA, Ince C, Whipp BJ, Mythen MG, Montgomery HE, Grocott MP, Feelisch M; Caudwell Extreme Everest Research Group. (2011) The role of nitrogen oxides in human adaptation to hypoxia. Sci Rep. 2011;1:109.

Elbers PW, Prins WB, Plokker HW, van Dongen EP, van Iterson M, Ince C (2012) Electrical cardioversion for atrial fibrillation improves microvascular flow independent of blood pressure changes. J Cardiothorac Vasc Anesth 26(5):799-803.

Atasever B, van der Kuil M, Boer C, Vonk A, Schwarte L, Girbes AR, Ince C, Beishuizen A, Groeneveld AB (2012) Red blood cell transfusion compared with gelatin solution and no infusion after cardiac surgery: effect on microvascular perfusion, vascular density, hemoglobin, and oxygen saturation. Transfusion. 2012 Nov;52(11):2452-8.


320. Piagnerelli M, Ince C, Dubin A (2012) Microcirculation. Crit Care Res Pract. 2012:867176.

Yuruk K, Bezemer R, Euser M, Milstein DM, de Geus HH, Scholten EW, de Mol BA, Ince C (2012) The effects of conventional extracorporeal circulation versus miniaturized extracorporeal circulation on microcirculation during cardiopulmonary bypass-assisted coronary artery bypass graft surgery. Interact Cardiovasc Thorac Surg. 15(3):364-70.

Zacharowski K, Van Aken H, Marx G, Jacob M, Schaffartzik W, Zenz M, Loer SA, Ince C, Martin C, De Hert S, Hollmann MW, Girbes AR, Kozek-Langenecker S, Gombotz H, Guidet B, Della Rocca G, Wilson J, De Gasperi A. (2012) Comments on Reinhart et al.: consensus statement of the ESICM task force on colloid volume therapy in critically ill patients. Intensive Care Med 38(9):1556-7

Top AP, Buijs EA, Schouwenberg PH, van Dijk M, Tibboel D, Ince C (2012) The Microcirculation Is Unchanged in Neonates with Severe Respiratory Failure after the Initiation of ECMO Treatment. Crit Care Res Pract. 2012;2012:372956.

Bezemer R, Bartels SA, Bakker J, Ince C (2012) Clinical review: Clinical imaging of the sublingual microcirculation in the critically ill - where do we stand? Crit Care. 19;16(3):224-8

Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Bakker J, Ince C (2012) Study Design of the Microcirculatory Shock Occurrence in Acutely Ill Patients (microSOAP): an International Multicenter Observational Study of Sublingual Microcirculatory Alterations in Intensive Care Patients. Crit Care Res Pract.2012:121752.

Bartels SA, Stok WJ, Bezemer R, Boksem RJ, van Goudoever J, Cherpanath TG, van Lieshout JJ, Westerhof BE, Karemaker JM, Ince C (2012)Noninvasive cardiac output monitoring during exercise testing: Nexfin pulse contour analysis compared to an inert gas rebreathing method and respired gas analysis. J Clin Monit Comput. 25(5):315-21.

Yuruk K, Bartels SA, Milstein DM, Bezemer R, Biemond BJ, Ince C (2013) Red blood cell transfusions and tissue oxygenation in anemic hematology outpatients. Transfusion. 52(3):641-6.

Kompanje E, van Genderen M, Ince C (2012) The supine head-down tilt position that was named after the German surgeon Friedrich Trendelenburg European Surgery. Eur Surg 44/3: 168�171.
310 Vincent JL, Ince C, Bakker J. (2012) Clinical review: Circulatory shock - an update: a tribute to Professor Max Harry Weil. Crit Care. 20;16(6):239-243.

Piagnerelli M, Ince C, Dubin A.(2012) Microcirculation. Crit Care Res Pract.;2012:867176.

Hernandez G, Regueira T, Bruhn A, Castro R, Rovegno M, Fuentealba A, Veas E, Berrutti D, Florez J, Kattan E, Martin C, Ince C. (2012) Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study. Ann Intensive Care. 15;2(1):44.

Atasever B, van der Kuil M, Boer C, Vonk A, Schwarte L, Girbes AR, Ince C, Beishuizen A, Groeneveld AB (2012) Red blood cell transfusion compared with gelatin solution and no infusion after cardiac surgery: effect on microvascular perfusion, vascular density, hemoglobin, and oxygen saturation. Transfusion. 52(11):2452-8.
.
Zacharowski K, Van Aken H, Marx G, Jacob M, Schaffartzik W, Zenz M, Loer SA, Ince C, Martin C, De Hert S, Hollmann MW, Girbes AR, Kozek-Langenecker S, Gombotz H, Guidet B, Della Rocca G, Wilson J, De Gasperi A. (2012) Comments on Reinhart et al.: consensus statement of the ESICM task force on colloid volume therapy in critically ill patients. Intensive Care Med. 38(9):1556-7; author reply 1558-9.

Hernandez G, Boerma EC, Dubin A, Ince C (2012) Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality, and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients.
J of Crit Care 538.e9-538.

Smeele K, Eerbeek O, Schaart G, Koeman A, Bezemer R, Nelson J, Ince C, Nederlof R, Boek M, Laakso M, de Haan A, Drost M, Hollmann M, Zuurbier CJ (2012) Reduced hexokinase ii impairs muscle function two weeks after ischemia-reperfusion through increased cell necrosis and fibrosis. J Appl Physiol 113(4):608-18

Enrico C, Kanoore Edul V Vazquez A, Pein M, Pérez de la Hoz R, Ince C, Dubin A (2012) Systemic and microcirculatory effects of dobutamine in septic shock patients. J Crit Care (in press) 27(6):630-8

Milstein DM, Cheung YW, Ziūkaitė L, Ince C, van den Akker HP, Lindeboom JA (2012) An integrative approach for comparing microcirculation between normal and alveolar cleft gingiva in children scheduled for secondary bone grafting procedures.. Oral Surg Oral Med Oral Pathol Oral Radiol. 115(3):304-9

Ruiz C, Glenn Hernandez G, Andresen M, Ince C, Bruhn A (2012) Mini-report: Microcirculatory flow abnormalities in a patient with severe hyperviscosity syndrome Clinical Hemorheology and Microcirculation 54(1):33-8

300. Hernandez G, Pedreros C, Veas E, Bruhn A, Romero C, Rovegno M, Neira R, Bravo S, Castro R, Kattan E, Ince C. (2012 ) Evolution of peripheral vs metabolic perfusion parameters during septic shock resuscitation. A clinical-physiologic study. J Crit Care. 27(3):283-8.

Yuruk K, Bezemer R, Euser M, Milstein DM, de Geus HH, Scholten EW, de Mol BA, Ince C. (2012) The effects of conventional extracorporeal circulation versus miniaturized extracorporeal circulation on microcirculation during cardiopulmonary bypass-assisted coronary artery bypass graft surgery. Interact Cardiovasc Thorac Surg. 15(3):364-70

Pozo MO, Kanoore Edul VS, Ince C, Dubin A. (2012) Comparison of different methods for the callation of the microvascular flow index. Crit Care Res Pract. 2012:102483

Ozarslan NG, Ayhan B, Kanbak M, Celebioğlu B, Demircin M, Ince C, Aypar U. (2012) Comparison of the Effects of Sevoflurane, Isoflurane, and Desflurane on Microcirculation in Coronary Artery Bypass Graft Surgery.) J Cardiothorac Vasc Anesth. 26(5):791-8

Hernandez G, Bruhn A, Castro R, Pedreros C, Rovegno M, Kattan E, Veas E, Fuentealba A, Regueira T, Ruiz C, Ince C. (2012) Persistent Sepsis-Induced Hypotension without Hyperlactatemia: A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock. Crit Care Res Pract. 2012;2012:536852.

van Iterson M, Bezemer R, Heger M, Siegemund M, Ince C (2012) Microcirculation follows macrocirculation in heart and gut in the acute phase of hemorrhagic shock and isovolemic autologous whole blood resuscitation in pigs. Transfusion. 52:1552-9.

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Bakker J Ince C (2012) Study design of the Microcirculatory Shock Occurrencein Acutely ill Patients (microSOAP): an international multicenter observational study of sublingual microcirculatory alterations in intensive care patients. Crit Care Res Pract 2012;2012:

Aksu U, Bezemer R, Ince C (2012)Reply to letter:Aksu et al. Balanced vs unbalanced crystaloid resuscitation in a near fatal model of hemorrhagic shock and the the effects on renal oxygenation, oxidative stress, and inflammation Resuscitation. May 4. [ PMID: 22564404

290. Kompanje EJO, van Genderen M, Ince C (2012) The supine head-down tilt position that was named after the German surgeon Friedrich Trendelenburg European Surgery 44: 168-171.

Milstein DM, v. Kuijen A, Copper MP, Karakullukcu B, Tan B, Lindeboom JAH, Fokkens W J, Ince C. (2012) Monitoring microcirculatory alterations in oral squamous cell carcinoma following photodynamic therapy. Photodiagnosis and Photodynamic Therapy 9(1):69-75.

Bezemer R, Bartels SA, Bakker J, Ince C (2012) Microcirculation-targeted therapy � almost there. Crit Care 19;16(3):224-228.

Yuruk K, Bezemer R, Ince C (2012) The efficacy of red blood cell transfusions to reach the microcirculation depends on the quality of storage and the condition of the patient. Yearbook of Intensive Care and Emergency Medicine. Ed JLVincent pp

Aksu U, Bezemer R, Demirci C, Ince C (2012) Acute effects of balanced versus unbalanced colloid resuscitation on renal macrocirculatory and microcirculatory perfusion during endotoxemic shock. Shock. 37(2):205-9.

Almac E, Aksu U, Bezemer R, Jong W, Kandil A, Yuruk K, Demirci-Tansel C,
Ince C.(2012) The acute effects of acetate-balanced colloid and crystalloid resuscitation on
renal oxygenation in a rat model of hemorrhagic shock Resuscitation 83(9):1166-7

Aksu U, Bezemer R, Yavuz B, Kandil A, Demirci C, Ince C. (2012) Balanced vs unbalanced crystalloid resuscitation in a near-fatal model of hemorrhagic shock and the effects on renal oxygenation, oxidative stress, and inflammation. Resuscitation. 83(6):767-73.

Kanoore Edul VS, Dubin A, Ince C. (2011) The microcirculation as a therapeutic target in the treatment of sepsis and shock. Semin Respir Crit Care Med. 32(5):558-68.

280 Aksu U, Demirci C, Ince C (2011) The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide. Contrib Nephrol.174:119-28.

Yuruk K, Bartels SA, Milstein DM, Bezemer R, Biemond BJ, Ince C. (2011) Red blood cell transfusions and tissue oxygenation in anemic hematology outpatients. Transfusion 52(3):641-6.

Bezemer R, Dobbe JG, Bartels SA, Christiaan Boerma E, Elbers PW, Heger M, Ince C.
(2011) Rapid automatic assessment of microvascular density in sidestream dark field images.
Med Biol Eng Comput. 49(11):1269-78.

Bartels SA, Stok WJ, Bezemer R, Boksem RJ, van Goudoever J, Cherpanath TG, van Lieshout JJ, Westerhof BE, Karemaker JM, Ince C (2011) Noninvasive cardiac output monitoring during exercise testing: Nexfin pulse contour analysis compared to an inert gas rebreathing method and respired gas analysis. J Clin Monit Comput. 25(5):315-21

Kanoore Edul VS, Enrico C Laviolle B, Vazquez AR, Ince C, Dubin A (2011) Quantitative assessment of the microcirculation in healthy volunteers and in septic shock patients Crit Care Med. 40(5):1443-1448

Boerma EC, Kaiferová K, Konijn AJ, De Vries JW, Buter H, Ince C (2011)
Rectal microcirculatory alterations after elective on-pump cardiac surgery. Minerva Anestesiol. 77(7):698-703

Ruiz C, Bruhn A, Ince C. (2011) Rol de la microcirculación y de la mitocondria en la falla orgánica múltiple asociada a la sepsis.' In: Sepsis. Y falla multiorgánica (eds; Castro J, Hernandéz G, Bruhn A, Romero C.)

270. Hernandez G, Pedreros C, Veas E, Bruhn A, Romero C, Rovegno M, Neira R, Bravo S, Castro R, Kattan E, Ince C. (2011) Evolution of peripheral vs metabolic perfusion parameters during septic shock resuscitation. A clinical-physiologic study. J Crit Care. 27(3):283-8

Kanoore Edul VS, Dubin A, Ince C (2011) The microcirculation as a therapeutic target in the treatment of sepsis and shock. Semin Respir Crit Care Med. 32(5):558-68

Edul VS, Ferrara G, Pozo MO, Murias G, Martins E, Canullén C, Canales HS, Estenssoro E, Ince C, Dubin A (2011) Failure of nitroglycerin (glyceryl trinitrate) to improve villi hypoperfusion in endotoxaemic shock in sheep. Crit Care Resusc. 13(4):252-61
Atasever B, Boer C, Speekenbrink R, Seyffert J, Goedhart P, de Mol B, Ince C (2011) Cardiac displacement during off-pump coronary artery bypass grafting surgery: effect on sublingual microcirculation and cerebral oxygenation. Interact Cardiovasc Thorac Surg. 13(6):573-7.
Bartels B, Bezemer B, Milstein D, Radder M, Lima A, Cherpanath A, Heger M, Karemaker JM, Ince C (2011) The microcirculatory response to compensated hypovolemia in a lower body negative pressure model. Microvasc Res. 82(3):374-80.

Bezemer R, Dobbe J, Bartels SA, Boerma EC, Elbers PWG, Heger M, Ince C (2011) Rapid automatic assessment of microvascular density in sidestream dark field images. Med Biol Eng Comput. 49(11):1269-78.

Atasever B, Boer C, Goedhart P, Biervliet J, Seyffert J, Speekenbrink R, Schwarte L, de Mol B, Ince C (2011) Distinct alterations in sublingual microcirculatory blood flow and hemoglobin oxygenation in on-pump and off-pump coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 25(5):784-90.
260. Dyson A, Bezemer R, Legrand M, Balestra G, Singer M, Ince C (2011) Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia. Shock. 36(1):83-9
Pérez-Bárcena J, Goedhart P, Ibáñez J, Brell M, García R, Llinás P, Jiménez C, Ince C. (2011) Direct observation of human microcirculation during decompressive craniectomy after stroke. Crit Care Med. 39(5):1126-923
Yuruk K, Almac E, Bezemer R, Goedhart P, de Mol B, Ince C. (2011) Blood transfusions recruit the microcirculation during cardiac surgery. Transfusion. 51(5):961-7.
Kanoore Edul V, Dubin A, Ince C (2011) The microcirculation as a therapeutic target in the treatment of sepsis and shock. Semin Respir Crit Care Med. 32(5):558-68

Aksu U, Demirci C, Ince C (2011) The pathogenesis of Acute Kidney Injury (AKI) and the toxic triangle of oxygen, reactive oxygen species and nitric oxide. In Pathophysiology of Sepsis- Induced Acute Kidney Injury Kellum JA, Ronco C, Vincent J- L (eds): Controversies in Acute Kidney Injury. Contrib Nephrol. Basel, Karger, 2011, vol 174, pp 1�10
Legrand M, Bezemer R, Payen D, Ince C (2011) The role of renal hypoperfusion in the development of renal microcirculatory dysfunction in endotoxemic rats. Intensive Care Med 37(9):1534-42.
Legrand M, Kandil A, Payen D, Ince C. (2011) Effects of Sepiapterin Infusion on Renal Oxygenation and Early Acute Renal Injury Following Supra-Renal Aortic Clamping in Rats. J Cardiovasc Pharmacol. 58(2):192-8.

Lima A, van Bommel J, Sikorska K, van Genderen M, Klijn E, Lesaffre E, Ince C, Bakker J.
(2011) The relation of near-infrared spectroscopy with changes in peripheral circulation in critically ill patients. Crit Care Med. 39(7):1649-54

Boerma EC, Kaiferová K, Konijn AJ, De Vries JW, Buter H, Ince C. (2011) Rectal microcirculatory alterations after elective on-pump cardiac surgery. Minerva Anestesiol. 77(7):698-703

Top AP, Ince C, Schouwenberg PH Tibboel D (2011) Inhaled nitric oxide improves systemic microcirculation in infants with hypoxemic respiratory failure. Pediatr Crit Care Med. Nov;12(6):e271-4.

Khalilzada M, Dogan K, Ince C, Stam J. (2011) Sublingual Microvascular Changes in Patients With Cerebral Small Vessel Disease. Stroke. 42(7):2071-3.

250. McMorrow RC, Windsor JS, Mythen MG, Grocott MP; Caudwell Xtreme Everest Research Group. (2011) A novel ambulatory closed circuit breathing system for use during exercise. Anaesthesia. 66(5):348-53

Mutalifu Y, Holm L, Ince C, Theodorsson E, Sjöberg F (2011). Multiple different laminar velocity profiles in separate veins in the microvascular network of brain cortex in rats. Int J Clin Exp Med 4(1):10-6.

Bartels SA, Bezemer R, Wallis de Vries FJ, Milstein DMJ, Lima A, Cherpanath TGV, van den Meiracker AH, Heger M, Karemaker JM, Ince C (2011) Multi-site and multi-depth near-infrared spectroscopy in a model of simulated (central) hypovolemia: lower body negative pressure. Intensive Care Med 37(4):671-7.

Atasever B, Boer C, van der Kuil M, Lust E, Beishuizen A, Speekenbrink R, Seyffert J, de Mol B, Ince C (2011) Quantitative Imaging of Microcirculatory Response During Nitroglycerin-Induced Hypotension.J Cardiothorac Vasc Anesth. 25(1):140-4.

Top AP, Ince C, de Meij N, van Dijk M, Tibboel D. (2011) Persistent low microcirculatory vessel density in non survivors of sepsis in the pediatric intensive care. Crit Care Med. 39(1):8-13

Top AP, van Dijk M, van Velzen JE, Ince C, Tibboel D (2011)Functional capillary density decreases after the first week of life in term neonates. Neonatology. 99(1):73-7.

Wilson MH, Edsell ME, Davagnanam I, Hirani SP, Martin DS, Levett DZ, Thornton JS, Golay X, Strycharczuk L, Newman SP, Montgomery HE, Grocott MP, Imray CH; Caudwell Xtreme Everest Research Group. (2011) Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia--an ultrasound and MRI study. J Cereb Blood Flow Metab. 2011 Oct;31(10):2019-29.


Holloway CJ, Montgomery HE, Murray AJ, Cochlin LE, Codreanu I, Hopwood N, Johnson AW, Rider OJ, Levett DZ, Tyler DJ, Francis JM, Neubauer S, Grocott MP, Clarke K; Caudwell Xtreme Everest Research Group.(2011) Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. FASEB J. 25(2):792-6.

can ince