Rupert Pearse graduated in 1996 from St George's Hospital Medical School, London, UK. After time working in general medicine and anaesthesia, he returned to St George's Hospital where he developed many of his current research interests and completed his training in Intensive Care Medicine. In 2006, he was appointed Senior Lecturer in Intensive Care Medicine at Barts and The London School of Medicine and Dentistry and was promoted to Reader in 2011. He has now given up anaesthesia to concentrate on his clinical duties on the intensive care unit at The Royal London Hospital and his research interests in improving outcomes following major surgery and the cardiovascular pathophysiology of critical illness. Rupert plays a leading role in a number of large multi-centre studies including OPTIMISE, EuSOS and VISION.