Evan D. Kharasch, MD, PhD is the Merel H. Harmel Professor of Anesthesiology and Vice Chair for Innovation in the Department of Anesthesiology at Duke University, and also the Director of Academic Entrepreneurship in Duke University School of Medicine. He is also the Editor-in-Chief of Anesthesiology, the leading journal in the specialty. He is an elected member of the National Academy of Medicine (Institute of Medicine).
Dr. Kharasch is one of the foremost experts and proponents of perioperative methadone use, having authors the seminal article on its reintroduction to the specialty (Anesth Analg. 2011; 112: 13–16). He leads an active research program in basic, translational and clinical pharmacology, and is a practicing anesthesiologist. His research broadly addresses anesthetic and analgesic drugs and addiction therapies, directed towards optimizing drug disposition, drug safety, clinical effectiveness and patient satisfaction. Specific interests include drug metabolism and transport, pharmacokinetics, pharmacodynamics, pharmacogenetics, toxicity, drug interactions, and variability in patient response, as well as perioperative pain and analgesia. His research on opioids has led to more rational use and greater patient safety, and improved regulation. His research led to the regulatory approval of sevoflurane, the most widely used volatile anesthetic in the world, having benefitted more than 1 billion patients. He has authored more than 290 peer reviewed research and scholarly articles, as well as numerous book chapters, and is the editor of two major textbooks on anesthetic pharmacology. His research has been continuously federally funded for 30 years.